Combination Therapies as a Strategy Against Resistance
Combination therapy has emerged as a leading approach to overcome PD-1 resistance. By targeting multiple pathways simultaneously, clinicians aim to prevent cancer cells from adapting.
Combining immunotherapy with radiation, chemotherapy, or targeted agents can enhance immune activation and tumor vulnerability. Radiation, for example, may increase antigen release, making tumors more visible to the immune system.
The goal of combination therapy is synergy—achieving greater effectiveness without excessive toxicity. Careful patient selection and dosing strategies are critical to success.
Combination approaches reflect a shift away from single-agent reliance toward integrated cancer care.
3 Views